6

Cambridge, Massachusetts

Member, Nominating & Corporate Governance Committee of the Board of Directors

2/2022

7

Cambridge, Massachusetts

Member, Board of Directors

2/2022

2

Cambridge, Massachusetts

Pursuant to the terms of the company's Amended and Restated Stock Option Incentive Plan, the Administrator of the company was authorized to and agreed to accelerate the vesting of my unvested stock options that vested prior to February 19, 2022. I divested my vested shares in March 2022. I forfeited my unvested options upon my resignation; those options were canceled. I do not hold any equity interests in the company.

1/2021

5

Cambridge, Massachusetts

Member, Nominating & Corporate Governance Committee of the Board of Directors

Present

6

Cambridge, Massachusetts

Member, Board of Directors

Present

2

Cambridge, Massachusetts

Pursuant to my agreement with the company, I am entitled to receive any outstanding board of director’s fees and committee fees pro-rated through the date of my resignation. The company will make these payments to me in the month following the end of the quarter. Additionally, and pursuant to the terms of the companies Amended and Restated Stock Option Incentive Plan, the Administrator of the company is authorized to and has agreed to accelerate the vesting of my unvested stock options that vest prior to February 19, 2022. After February 19, 2022, my options vest on a monthly basis. Any remaining unvested options will be forfeited upon resignation. Pursuant to the terms of the plan, I have 90 days to exercise my vested options.

1/2021

1

Cambridge, Massachusetts

Member, Board of Directors; and Member, Nominating & Corporate Governance Committee of the Board of Directors

5

Cambridge, Massachusetts

Member, Nominating & Corporate Governance Committee of the Board of Directors

Present

6

Cambridge, Massachusetts

Member, Board of Directors

Present

2

Cambridge, Massachusetts

Pursuant to my agreement with the company, I am entitled to receive any outstanding board of director’s fees and committee fees pro-rated through the date of my resignation. The company will make these payments to me in the month following the end of the quarter. Additionally, and pursuant to the terms of the companies Amended and Restated Stock Option Incentive Plan, the Administrator of the company is authorized to and has agreed to accelerate the vesting of my unvested stock options that vest prior to February 19, 2022. After February 19, 2022, my options vest on a monthly basis. Any remaining unvested options will be forfeited upon resignation. Pursuant to the terms of the plan, I have 90 days to exercise my vested options.

1/2021

1

Cambridge, Massachusetts

Member, Board of Directors; and Member, Nominating & Corporate Governance Committee of the Board of Directors